cMyc increases cell number through uncoupling of cell division from cell size in CHO cells |
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| Authors: | Darrin Kuystermans and Mohamed Al-Rubeai |
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| Affiliation: | (1) School of Chemical and Bioprocess Engineering, University College Dublin, Delfield, Dublin 4, Ireland;(2) Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland |
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| Abstract: | Background Over the past decades, the increase in maximal cell numbers for the production of mammalian derived biologics has been in a large part due to the development of optimal feeding strategies. Engineering of the cell line is one of probable approaches for increasing cell numbers in bioreactor. |
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