Strong teratocarcinoma transplantation loci,Gt-1 and Gt-2, Flank H-2 |
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| Authors: | Alexandra Shedlovsky Linda J Clipson John L VandeBerg William F Dove |
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| Institution: | (1) McArdle Laboratory, University of Wisconsin, 53706 Madison, Wisconsin;(2) Laboratory of Genetics, University of Wisconsin, 53706 Madison, Wisconsin;(3) Alexandra Shedlovsky, McArdle Laboratory, University of Wisconsin, 53706 Madison, Wisconsin;(4) Present address: Genetics Program, Southwest Foundation for Research and Education, P. O. Box 28147, 78284 San Antonio, Texas |
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| Abstract: | Evidence is presented for the existence of two strong murine teratocarcinoma transplantation antigens (Gt) on the cell line PCC3. It is shown that the loci governing expression of these antigens are linked to the H-2 complex. These loci have been further mapped with respect to the brachyury marker (T) and H-2: Gt-1 lies 5±2 crossover units proximal to H-2 and 12±2 crossover units distal to T, Gt-2 lies 21±4 crossover units distal to H-2. It is possible that these strong transplantation antigens provide an embryonic analogue to the adult major histocompatibility system. |
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