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C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
Affiliation:1. Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases, NIH, Bethesda, MD, USA;2. Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA;3. Departments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN, USA;4. Duke Clinical Research Institute, Durham, NC, USA;5. Department of Medicine, Division of Infectious Diseases, Duke University, Durham, NC, USA;6. Department of Genetics, University of Groningen, Groningen, the Netherlands;7. Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA;9. Complement and Inflammation Research Section, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA;10. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;11. Department of Biological Sciences, University of Toledo, Toledo, OH, USA;12. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University, Nijmegen, the Netherlands;13. Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany;1. Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA;2. Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA;3. Department of Computer Science, Department of Physics and Astronomy, Hotchkiss Brain Institute, Alberta Children’s Research Hospital, University of Calgary, Calgary, AB, Canada;1. Institut Pasteur, Université Paris Cité, CNRS UMR6047, Archaeal Virology Unit, Paris 75015, France;2. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA;3. Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA;4. Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation, College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China;5. O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233, USA;1. Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA;2. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain;3. Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA;4. Departments of Cell Biology and Dermatology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA;1. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel;2. Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel;1. Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China;2. Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China;3. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;5. Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, China;6. IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, China;1. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA;2. Department of Genetics, Harvard Medical School, Boston, MA 02114, USA;3. Center for Quantitative Health Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA;4. Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Abstract:
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  • Keywords:complement  C5  C5aR1  candidemia  candidiasis  kidney  eculizumab  avacopan
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