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Vaccine elicitation and structural basis for antibody protection against alphaviruses
Institution:1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;2. Vaccine Research Center Electron Microscopy Unit, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA;3. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA;4. Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA;5. Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA;6. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;7. Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, MD 21702, USA;8. Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA;1. Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA;2. Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA;3. Department of Computer Science, Department of Physics and Astronomy, Hotchkiss Brain Institute, Alberta Children’s Research Hospital, University of Calgary, Calgary, AB, Canada;1. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel;2. Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel;1. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;2. Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA;3. Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA;1. Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases, NIH, Bethesda, MD, USA;2. Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA;3. Departments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN, USA;4. Duke Clinical Research Institute, Durham, NC, USA;5. Department of Medicine, Division of Infectious Diseases, Duke University, Durham, NC, USA;6. Department of Genetics, University of Groningen, Groningen, the Netherlands;7. Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA;9. Complement and Inflammation Research Section, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA;10. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;11. Department of Biological Sciences, University of Toledo, Toledo, OH, USA;12. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University, Nijmegen, the Netherlands;13. Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany;1. Department of Biochemistry and BioFrontiers Institute, University of Colorado-Boulder, Boulder, CO 80303, USA;2. Guangzhou Laboratory, Guangzhou, Guangdong, China;3. Experimental Oncology Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain;4. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain;5. Department of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado-Boulder, Boulder, CO 80303, USA;6. Oncology Research & Development, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA
Abstract:
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  • Keywords:alphavirus  broadly neutralizing antibody  cryo-EM  vaccine
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