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Comparative landscape of genetic dependencies in human and chimpanzee stem cells
Institution:1. Whitehead Institute for Biomedical Research, Cambridge, MA, USA;2. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA;3. Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA;4. Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA, USA;5. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA;6. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA;7. Department of Neurology, University of California, San Francisco, San Francisco, CA, USA;8. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute Technology, Cambridge, MA 02142, USA
Abstract:
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  • Keywords:human-specific evolution  CRISPR screening  genetic dependencies  cellular anthropology  pluripotent stem cells  neural progenitor cells  G1-phase length hypothesis
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