首页 | 本学科首页   官方微博 | 高级检索  
     


Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation
Affiliation:1. State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China;2. Shanghai Institute of Immunology, Department of Immunology and Microbiology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;3. Department of Mathematics, Shanghai Normal University, Shanghai 200234, China;4. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China;5. Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;6. School of Life Sciences, Fudan University, Shanghai 200438, China;7. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;8. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, 141-83 Stockholm, Sweden;9. Kindstar Global Precision Medicine Institute, Wuhan 430000, China;10. School of Biosciences, University of Chinese Academy of Sciences, Beijing 101499, China;11. Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China;12. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden;13. State Key Laboratory of Farm Animal Biotech Breeding, China Agricultural University, Beijing 100193, China;14. Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China;15. Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;16. Shanghai Huashen Institute of Microbes and Infections, Shanghai 200052, China;1. Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK;2. Centre of Membrane Proteins and Receptors (COMPARE), Universities of Nottingham and Birmingham, Birmingham B15 2TT, UK;3. Research Program on Biomedical Informatics, Hospital del Mar Medical Research Institute, Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, 08003, Spain;4. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India;5. School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK;6. Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen''s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK;7. Institut für Molekulare Zellbiologie, Center for Molecular Biomedicine, Universitätsklinikum Jena, Friedrich-Schiller-Universität, Jena 07745, Germany;8. Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK;1. Centre for Cell Biology of Chronic Disease, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia;2. School of Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD Bristol, UK;3. MRC Laboratory of Molecular Biology, CB2 0QH Cambridge, UK;4. Department of Biochemistry and Pharmacology, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia;5. School of Biological Sciences, University of Bristol, BS8 1TD Bristol, UK;6. Cambridge Institute for Medical Research, University of Cambridge, CB2 0XY Cambridge, UK;7. Institute of Health and Sport (iHeS), Victoria University, Melbourne, VIC Australia;8. Proteomics Facility, School of Biochemistry, Biomedical Sciences Building, University of Bristol, BS8 1TD Bristol, UK;9. Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;10. Max Planck Bristol Centre for Minimal Biology, Department of Chemistry, University of Bristol, BS8 1TS Bristol, UK;11. Murdoch Children’s Research Institute, Royal Children’s Hospital, Melbourne, VIC Australia;1. State Key Laboratory of Membrane Biology, Peking-Tsinghua Joint Center for Life Sciences, School of Life Sciences, Peking University, Beijing 100871, China;2. Changping Laboratory, Beijing 102206, China;3. Changping Laboratory Graduate Program, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China;4. MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China;5. National Institute of Biological Sciences, Beijing 102206, China;6. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 100084, China;7. National Biomedical Imaging Center, Peking University, Beijing 100871, China;1. Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA;2. Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA;1. Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA;2. Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, 81675 Munich, Germany;3. Center for Organoid Systems, Technical University of Munich, 85748 Garching, Germany;4. TranslaTUM – Organoid Hub, Technical University of Munich, 81675 Munich, Germany;5. Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel;6. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA;7. Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA;1. Research Institute of Molecular Pathology, Vienna BioCenter, 1030 Vienna, Austria;2. Saarland University, Organic Chemistry I, 66123 Saarbrücken, Germany;3. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), 66123 Saarbrücken, Germany;4. Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, 40225 Düsseldorf, Germany;5. Boehringer Ingelheim RCV GmbH & Co KG, 1120 Vienna, Austria;6. University of Duisburg-Essen, Center of Medical Biotechnology, Faculty of Biology, 45141 Essen, Germany;7. School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia;8. Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, NSW 2006, Australia;9. Max Perutz Labs, Vienna BioCenter, 1030 Vienna, Austria;10. Medical University of Vienna, 1030 Vienna, Austria;11. Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, 1030 Vienna, Austria;12. University of Vienna, Center for Molecular Biology, Department for Biochemistry and Cell Biology, 1030 Vienna, Austria
Abstract:
><ol class=
  • Download : Download high-res image (163KB)
  • Download : Download full-size image
  • Keywords:somatic hypermutation  affinity maturation  complementarity-determining region  AID  deaminase
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号