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Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility
Institution:1. Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, Zhejiang, China;2. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, Zhejiang, China;3. Institute of Biology, Westlake Institute for Advanced Study, Hangzhou 310024, Zhejiang, China;4. State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China;5. State Key Laboratory of Reproductive Medicine and Offspring Health, The Center for Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;6. Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China;7. Liangzhu Laboratory, Zhejiang University, Hangzhou 311121, Zhejiang, China;8. State Key Laboratory of Reproductive Medicine and Offspring Health, The Affiliated Taizhou People''s Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Nanjing 211166, China;9. Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China;1. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel;2. Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel;1. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;2. Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA;3. Department of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA;1. Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;3. Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;4. Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA;5. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;6. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;7. Program for Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;8. Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA;9. Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;10. Duchossois Family Institute, University of Chicago, Chicago, IL 60637, USA;1. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;2. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119234, Russia;3. Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey;4. i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal;5. Aging and Aneuploidy Laboratory, IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal;6. Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA;7. Quantitative Medicine and Systems Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA;8. Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA;9. Broad Institute, Cambridge, MA, USA;1. Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA;2. Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA;3. Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA;4. Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
Abstract:
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  • Keywords:doublet microtubule  sperm flagella  sperm motility  microtubule inner proteins  Tektin5  FAM166 family  male infertility  asthenozoospermia  cryo-EM
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