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TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
Institution:1. KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Rega Institute, Leuven 3000, Belgium;2. Chromatin Structure and Mobile DNA Laboratory, Francis Crick Institute, London NW1 1AT, UK;3. Structural Biology of Disease Processes Laboratory, Francis Crick Institute, London NW1 1AT, UK;4. Department of Chemistry, Britannia House, 7 Trinity Street, King''s College London, London SE1 1DB, UK;5. Structural Biology Science Technology Platform, Francis Crick Institute, London NW1 1AT, UK;6. LonCEM Facility, Francis Crick Institute, London NW1 1AT, UK;7. KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Virology and Chemotherapy, Translational Platform Virology and Chemotherapy, Rega Institute, Leuven 3000, Belgium;8. KU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute, Leuven 3000, Belgium;9. KU Leuven Department of Imaging and Pathology, Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research Unit, Leuven 3000, Belgium;10. Alector LLC, 131 Oyster Point Blvd. Suite 600, South San Francisco, CA 94080, USA;11. Department of Infectious Disease, Section of Virology, Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK
Abstract:
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  • Keywords:SARS-CoV-2  entry receptor  TMEM106B  coronavirus  ACE2-independent entry  antibody neutralization  cryo-EM  TMEM106B crystal structure
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