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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Affiliation:1. David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA;2. Department of Materials Science and Engineering, MIT, Cambridge, MA 02139, USA;3. Department of Biological Engineering, MIT, Cambridge, MA 02139, USA;4. Department of Chemical Engineering, MIT, Cambridge, MA, USA;5. Ragon Institute of Massachusetts General Hospital, Cambridge, MA 02139, USA;6. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;7. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;8. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;9. The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA;10. Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
Abstract:
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  • Keywords:chimeric antigen receptor T cell  CAR T  vaccine  antigen spreading  IFN-γ  cancer  solid tumor  antigen loss  antigenic heterogeneity  tumor heterogeneity  immunotherapy
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