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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Institution:1. Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;2. Department of Biological Sciences, Department of Chemistry, Columbia University, New York, NY 10027, USA;3. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;4. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;5. Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA;1. Institut Pasteur, Université Paris Cité, CNRS UMR6047, Archaeal Virology Unit, Paris 75015, France;2. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA;3. Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35233, USA;4. Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation, College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China;5. O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233, USA;1. Beijing Advanced Innovation Center for Structural Biology & Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China;2. Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China;3. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;5. Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao 266237, China;6. IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, China;1. Department of Biochemistry and BioFrontiers Institute, University of Colorado-Boulder, Boulder, CO 80303, USA;2. Guangzhou Laboratory, Guangzhou, Guangdong, China;3. Experimental Oncology Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain;4. Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain;5. Department of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado-Boulder, Boulder, CO 80303, USA;6. Oncology Research & Development, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA;1. Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA;2. Cell Signaling Technology, Inc., Danvers, MA, USA;3. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA;4. Division of Cardiology, Harvard Medical School, Boston, MA, USA;5. Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA;6. Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA;7. Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USA;8. Division of Nephrology, Harvard Medical School, Boston, MA, USA;9. Department of Medicine, Massachusetts General Hospital, Boston, MA, USA;10. Department of Medicine, Harvard Medical School, Boston, MA, USA;11. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA;12. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA;1. Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA;2. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;3. Evergrande Center for Immunologic Diseases, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA 02115, USA;4. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;5. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;6. Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA;7. Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany;8. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;9. Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;10. Center for Engineering in Medicine and Shriners Hospital for Children, Harvard Medical School, Boston, MA 02114, USA;1. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;2. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119234, Russia;3. Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkey;4. i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal;5. Aging and Aneuploidy Laboratory, IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal;6. Departments of Biology and Medicine, University of Rochester, Rochester, NY, USA;7. Quantitative Medicine and Systems Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA;8. Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109, USA;9. Broad Institute, Cambridge, MA, USA
Abstract:
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  • Keywords:MBOAT1  MBOAT2  phospholipid remodeling  sex hormone signaling  ferroptosis  androgen receptor  estrogen receptor
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