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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
Affiliation:1. Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA;2. Cell Signaling Technology, Inc., Danvers, MA, USA;3. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA;4. Division of Cardiology, Harvard Medical School, Boston, MA, USA;5. Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA, USA;6. Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA;7. Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USA;8. Division of Nephrology, Harvard Medical School, Boston, MA, USA;9. Department of Medicine, Massachusetts General Hospital, Boston, MA, USA;10. Department of Medicine, Harvard Medical School, Boston, MA, USA;11. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA;12. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA;1. Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA;2. Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA;3. Department of Computer Science, Department of Physics and Astronomy, Hotchkiss Brain Institute, Alberta Children’s Research Hospital, University of Calgary, Calgary, AB, Canada;1. Department of Automation, Tsinghua University, Beijing 100084, China;2. Institute for Brain and Cognitive Sciences, Tsinghua University, Beijing 100084, China;3. Beijing Key Laboratory of Multi-dimension & Multi-scale Computational Photography (MMCP), Tsinghua University, Beijing 100084, China;4. IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, China;5. Hangzhou Zhuoxi Institute of Brain and Intelligence, Hangzhou 311100, China;6. Tsinghua-Peking Center for Life Sciences, Beijing 100084, China;7. Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing 100084, China;8. Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China;9. Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518071, China;10. Department of Anesthesiology, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China;11. Beijing Key Laboratory for Immunological Research on Chronic Diseases, Tsinghua University, Beijing 100084, China;12. Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing 100084, China;1. Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA;2. Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain;3. Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA;4. Departments of Cell Biology and Dermatology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA;1. Department of Biochemistry & Biophysics, Texas A&M University, College Station, TX 77843, USA;2. National Key Laboratory of Agricultural Microbiology, Hubei Key Laboratory of Plant Pathology, Hubei Hongshan Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China;3. State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai’an, Shandong 271018, China;4. College of Life Science and Technology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, Hubei 430070, China;5. Department of Biology, University of Mississippi, Oxford, MS 38677, USA;1. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA;2. Department of Genetics, Harvard Medical School, Boston, MA 02114, USA;3. Center for Quantitative Health Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA;4. Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA;1. Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases, NIH, Bethesda, MD, USA;2. Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA;3. Departments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN, USA;4. Duke Clinical Research Institute, Durham, NC, USA;5. Department of Medicine, Division of Infectious Diseases, Duke University, Durham, NC, USA;6. Department of Genetics, University of Groningen, Groningen, the Netherlands;7. Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA;9. Complement and Inflammation Research Section, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA;10. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA;11. Department of Biological Sciences, University of Toledo, Toledo, OH, USA;12. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University, Nijmegen, the Netherlands;13. Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany
Abstract:
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  • Keywords:nuclear ROS  CHK1  mitochondrial translation  chemical proteomics  chemoresistance  nucleus-to-mitochondria signaling
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