Structure-activity relationships of organosulfur compounds as inhibitors of cytochrome P450 1-mediated activation of benzo[a]pyrene in a human cell model |
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Authors: | Hyun Jung Kim Hyang Sook Chun |
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Institution: | (1) Korea Food Research Institute, Sungnam, 463-746, Korea;(2) Korea Food Research Institute, Sungnam, 463-746, Korea |
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Abstract: | Twelve naturally-occurring organosulfur compounds were investigated as inhibitors of cytochrome P450 1 (CYP450 1)-mediated activation of benzoa]pyrene (Ba]P) in human hepatoma (HepG2) cells. Inhibition depended on the presence of a diallyl group and the number of S atoms. Diallyl trisulfide (DATS), with a diallyl group and three S atoms, had the highest activity with an IC50 of 0.4 mM, and 1.5-fold higher potency than diallyl disulfide (DADS) containing a diallyl group and two S atoms. Organosulfur compounds containing an alkyl group were less effective, or even ineffective, inhibitors of both CYP450 1 and Ba]P-induced cytotoxicity than DADS and DATS. Alliin and S-allyl cysteine containing the S-cysteinyl group had no inhibition. |
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Keywords: | benzo[a]pyrene cytochrome P450 1 human hepatoma cell organosulfur compounds |
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