Localization of Human Flavin-Containing Monooxygenase GenesFMO2andFMO5to Chromosome 1q |
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| Authors: | RR McCombie CT Dolphin S Povey IR Phillips EA Shephard |
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| Institution: | aDepartment of Biochemistry and Molecular Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom;bDepartment of Biochemistry, Queen Mary and Westfield College, University of London, Mile End Road, London, E1 4NS, United Kingdom;cMRC Human Biochemical Genetics Unit and the Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, United Kingdom |
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| Abstract: | The human flavin-containing monooxygenase (FMO) gene family comprises at least five distinct members (FMO1toFMO5) that code for enzymes responsible for the oxidation of a wide variety of soft nucleophilic substrates, including drugs and environmental pollutants. Three of these genes (FMO1, FMO3,andFMO4) have previously been localized to human chromosome 1q, raising the possibility that the entire gene family is clustered in this chromosomal region. Analysis by polymerase chain reaction of DNA isolated from a panel of human–rodent somatic cell hybrids demonstrates that the two remaining identified members of theFMOgene family,FMO2andFMO5,also are located on chromosome 1q. |
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