| 肥胖诱发胰岛素抵抗的炎性机制 |
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| 引用本文： | 杨永青,杨明庆. 肥胖诱发胰岛素抵抗的炎性机制[J]. 中国生物化学与分子生物学报, 2012, 0(8): 692-699 |
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| 作者姓名： | 杨永青 杨明庆 |
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| 作者单位： | 山西师范大学生命科学学院;黄河水利职业技术学院 |
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| 基金项目： | 国家自然科学基金(No.30972091);山西省高等学校优秀青年学术带头人支持计划;山西师范大学自然科学基金(No.ZR09005);山西师范大学博士科研启动基金资助~~ |
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| 摘 要： | 肥胖可诱发一系列慢性代谢性疾病，如2型糖尿病、血脂障碍、高血压和非酒精性脂肪肝等.这些疾病构成了当今世界人类健康的极大威胁.胰岛素抵抗是这些疾病的共有特征.胰岛素抵抗的发生与慢性低度系统炎性密切相关，涉及多条炎性信号通路的激活和胰岛素信号转导的缺陷.本文综述了肥胖、炎性与胰岛素抵抗之间的本质联系，以及肥胖诱发胰岛素抵抗的炎性机制，以期为肥胖相关疾病的防治提供重要参考.
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| 关 键 词： | 肥胖 脂肪组织 炎性 胰岛素抵抗 |
| 收稿时间： | 2012-03-19 |
Inflammatory Mechanisms in Obesity-induced Insulin Resistance |
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| YANG Yong-Qing,YANG Ming-Qing. Inflammatory Mechanisms in Obesity-induced Insulin Resistance[J]. Chinese Journal of Biochemistry and Molecular Biology, 2012, 0(8): 692-699 |
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| Authors: | YANG Yong-Qing YANG Ming-Qing |
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| Affiliation: | 1)College of Life Sciences,Shanxi Normal University,Linfen 041000,Shanxi,China; 2)Yellow River Conservancy Technical Institute,Kaifeng 475004,Henan,China) |
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| Abstract: | Obesity induces chronic metabolic disorders,such as type 2 diabetes,dyslipidaemia,hypertension and nonalcoholic fatty liver,which endanger human health.Insulin resistance(IR) is common observed in these diseases.It has been demonstrated that the development of IR is associated with a mild state of chronic systemic inflammation with the activation of several inflammatory pathways and insulin signal transduction defects.This review discusses the recent advancement of connections among obesity,inflammation and IR.It might provide valuable information for the understanding of inflammatory mechanisms in obesity induces insulin resistance and help to develop new therapeutic approaches for obesity-related diseases. |
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| Keywords: | obesity adipose tissue inflammation insulin resistance |
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