| 整合素连接激酶与肿瘤 |
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| 引用本文： | 郝一昌[综述],;何培英,;徐涛,;王晓峰[审阅].整合素连接激酶与肿瘤[J].国外医学：分子生物学分册,2009(2):177-180. |
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| 作者姓名： | 郝一昌[综述] ;何培英 ;徐涛 ;王晓峰[审阅] |
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| 作者单位： | [1]北京大学人民医院泌尿外科,北京市100044; [2]北京大学人民医院中心实验室,北京市100044 |
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| 摘 要： | 整合素连接激酶（integrin—linked kinase，ILK）是一种Ser／Thr蛋白激酶。ILK可以与整合素结合，以依赖于P13K的方式激活，参与多种信号传导通路，包括整合素、生长因子及Wnt信号传导通路。ILK在调节细胞黏附、凋亡、铺展、迁移、生长、细胞周期、肿瘤形成等过程中发挥重要的作用。目前已经发现ILK在多种肿瘤中高表达，包括：神经胶母细胞瘤、黑色素瘤、胃癌、甲状腺肿瘤、卵巢癌、结肠癌、非小细胞肺癌和前列腺癌等。目前国内外大量实验证明ILK和肿瘤密切相关，所以ILK将成为肿瘤基因治疗和肿瘤药物的理想靶位点。
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| 关 键 词： | 整合素连接激酶 信号传导 基因治疗 |
Integrin-Linked Kinase and Tumor |
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| Institution: | HAO Yichang, HE Peiying, XU Tao, WANG Xiaofeng( 1Department of Urology, People＇ s Hospital, Peking University, Beifing , 100044, China 2Department of Center Laboratory, People＇s Hospital, Peking University, Belting, 100044, China ) |
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| Abstract: | Integrin-linked kinase （ILK） is a serine/threonine protein kinase, which can combine with integrin. ILK participates in series of signal transductions, such as integrin, growth factor and Wnt signal transduction. ILK plays an important role in cell attachment, spreading, migration, survival, cell cycle and so on. Moreover, it has been found that many tumors have high express of ILK, such as glioblastoma, melanoma, gastric carcinoma, thyroid tumor, ovarian cancer, colon cancer, non-small cell lung cancer, prostate cancer. Taken together, ILK might be an ideal target for human cancer gene therapy and medications. |
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| Keywords: | integrin-linked kinase signal transduction gene therapy |
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