| ACE2及其特殊功能 |
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| 引用本文： | 范英兰,李鹏飞,张源淑.ACE2及其特殊功能[J].国外医学：分子生物学分册,2009(2):148-150. |
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| 作者姓名： | 范英兰 李鹏飞 张源淑 |
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| 作者单位： | 南京农业大学农业部动物生理生化重点开放实验室,南京市210095 |
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| 基金项目： | 国家自然基金（No.30871838） |
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| 摘 要： | 血管紧张素转换酶2（angiotensin—converting enzyme 2，ACE2）是新发现的与血管紧张素转换酶（ACE）相关的羧肽酶，在肾素-血管紧张素系统（rennin-angiotensin system，RAS）中ACE2可以使AngⅡ转换为Ang1-7，从而产生与血管紧张素Ⅱ相反的效应，同时ACE2还可使Ang I转换为Ang1-9。研究发现：ACE2与高血压、SARS以及肾脏、生殖等系统的疾病有着密切的关系。
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| 关 键 词： | 血管紧张素转换酶2 肾素-血管紧张素系统 |
ACE2 and its Special Functions |
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| Authors: | FAN Yinlan LI Pengfei ZHANG Yuanshu |
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| Institution: | (The Animal Physiology and Biochemistry Laboratory of The Ministry of Agriculture in Nanjing Agriculture University, Nanjing, 210095, China) |
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| Abstract: | Angiotensin-converting enzyme 2 （ACE2） is a newly discovered peptide-carboxylase related to angiotensin-converting enzyme （ACE） . In renin-angiotensin system （RAS）, ACE2 converts Ang Ⅱ to Ang1-7, then promotes opposite effect of angiotensin ⅡIt also converts Ang I to Angl-9. It has been showed that ACE2 is closely involved in hypertension, SARS, and diseases of kidney and reproductive system. This review will focus on the structure, distribution, and function of ACE2. |
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| Keywords: | angiotensin-converting enzyme 2 rennin-angiotensin system |
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