| 体细胞克隆哺乳动物胚胎发育的表观遗传学 |
| |
| 引用本文： | 曹效彰,;任兆瑞. 体细胞克隆哺乳动物胚胎发育的表观遗传学[J]. 国外医学:分子生物学分册, 2009, 0(1): 45-48 |
| |
| 作者姓名： | 曹效彰, 任兆瑞 |
| |
| 作者单位： | [1]上海交通大学医学遗传研究所,上海市200040; [2]东北农业大学生命科学院,哈尔滨市150030 |
| |
| 基金项目： | 国家自然科学基金（No.30770242） |
| |
| 摘 要： | 如何提高克隆效率和体细胞核移植后表观遗传重编程的潜在机制的研究是当前生命科学的热点之一。将处于分化状态而进行核移植的体细胞转变成具有全能型的早期胚胎的关键是表观遗传的重编程。文章从基因印迹，x染色体失活，端粒长度等方面来探讨哺乳动物克隆胚胎在发育过程中的表观遗传重编程的机制。
|
| 关 键 词： | 体细胞克隆 表观遗传 甲基化 重编程 端粒 |
Epigenetics of Mammalian Embryonic Development by Somatic Cell Nuclear Transfer |
| |
| Affiliation: | CAO Xiaozhang, REN Zhaorui( 1 Shanghai Institute of Medical Genetics, Shanghai Jiaotong University, Shanghai, 200040, China 2.Life Science College, Northeast Agricultural University, Haerbin, 150030, China) |
| |
| Abstract: | How to improve efficiency of somatic cell cloning and potential mechanism of epigenetic reprogram after somatic cell nuclear transfer is one of the major interests in life science. Devel- opment of a differential somatic cell into a total-potential embryo is the key point of epigenetic reprogram. This review discusses the mechanisms of epigenetic reprogramming of cloned mammalian embryos in the aspect of gene imprinting, X-chromosome inactivation, telomere length and repair. |
| |
| Keywords: | somatic cell nuclear transfer epigenetic inherit methylation reprogram telomere |
| 本文献已被 维普 等数据库收录！ |
|
