| 平分型GlcNAc糖基化修饰的生物学功能 |
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| 引用本文： | 董芳,肖凡,魏红山. 平分型GlcNAc糖基化修饰的生物学功能[J]. 国外医学:分子生物学分册, 2009, 0(2): 138-143 |
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| 作者姓名： | 董芳 肖凡 魏红山 |
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| 作者单位： | 北京地坛医院首都医科大学传染病研究所北京市,100015 |
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| 基金项目： | 国家自然科学基金（No.30671875,30872243） |
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| 摘 要： | 平分型GlcNAc（bisecting N—acetylglucosamine）修饰是糖蛋白N-聚糖核心的常见分支修饰形式,哺乳类动物该糖基化修饰由β1,4-N-乙酰葡糖氨基转移酶Ⅲ催化。该修饰对分子结合、信号传导、生殖发育以及肿瘤细胞的生物学行为都有重要影响。相应地,针对平分型GlcNAc修饰N-聚糖的检测也正逐步成为糖生物学领域内的研究热点之一。
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| 关 键 词： | 糖蛋白 糖基化修饰 N-聚糖 平分型GlcNAc 糖基转移酶 |
Bisecting N-acetylglucosamine and its Biological Functions |
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| DONG Fang,XIAO Fan,WEI Hongshan. Bisecting N-acetylglucosamine and its Biological Functions[J]. , 2009, 0(2): 138-143 |
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| Authors: | DONG Fang XIAO Fan WEI Hongshan |
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| Affiliation: | (Beijing Ditan Hospital, The Institute of Infectious Dieuses, Capital Medical University, Beijing, 100015, China) |
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| Abstract: | The bisecting N-acetylglucosamine （GlcNAc） structure, formed through catalysis by UDP-N-acetylglucosamine： β-D-mannoside β-1, 4-N-acetylglucosaminyhansferase Ⅲ （GnT- Ⅲ ）, is responsible for a variety of biological functions, such as molecular recognition, reproduction, and phenotype regulation of tumor cells. Many investigations have been focused on the detection of bisecting GlcNAc in serum of patients during recent years. |
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| Keywords: | glycoprotein glycosylation N-glycan bisecting GIcNAc glyco transferases |
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