| 线粒体转运蛋白质家族 |
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| 引用本文： | 曾志锋,于淼,杨晓明. 线粒体转运蛋白质家族[J]. 国外医学:分子生物学分册, 2009, 0(2): 151-156 |
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| 作者姓名： | 曾志锋 于淼 杨晓明 |
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| 作者单位： | 军事医学科学院放射与辐射研究所,北京市100850 |
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| 摘 要： | 线粒体转运蛋白质家族（mitochondrial transporter family）等可溶性物质载体（solute carrier，SLC），主要包括SLC25，广泛存在于真核生物线粒体中，负责可溶性物质跨线粒体内膜的转运。SLC25家族成员拥有相似的结构特征、种类繁多的转运底物，并与细胞的多种生理功能密切相关。有研究表明，SLC25家族蛋白质的缺失或突变可导致多种代谢性疾病或神经系统疾病的发生。
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| 关 键 词： | 线粒体转运蛋白质家族 特征 生理功能 疾病 |
Members of Mitochondrial Transporter Family |
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| ZENG Zhifeng,YU Miao,YANG Xiaoming. Members of Mitochondrial Transporter Family[J]. , 2009, 0(2): 151-156 |
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| Authors: | ZENG Zhifeng YU Miao YANG Xiaoming |
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| Affiliation: | (Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing, 100850, China) |
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| Abstract: | The members of mitochondrial transporter family belong to solute cartier （SLC） groups, mainly including SLC25, which extensively exist in the mitochondria of eukaryotic cells and shuttle solute metabolites across the inner mitochondrial membrane. SLC25 proteins share distinct structural features, possess a great variety of transport substrates, and are closely involved in numerous physiological functions. It has been shown that defection or mutation of the members of mitochondrial transporter family may lead to various metabolism disorders or nervous system diseases. |
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| Keywords: | mitochondrial transporter family feature physiological function disease |
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