Biological activity of alpha-alkyl-amino acids |
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| Authors: | B. Lubec K. R. Herkner H. Brückner H. Höger J. Gialamas D. Adamiker G. Lubec |
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| Affiliation: | (1) Department of Pediatrics, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria;(2) Institute of Food Technology, University of Hohenheim, Stuttgart, Federal Republic of Germany;(3) Research Institute for Laboratory Animals Breeding, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria;(4) Ludwig Boltzmann Institute for Pediatric Endocrinology and Immunology, Vienna, Austria |
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| Abstract: | Summary A series of alpha-alkyl-amino acids were tested for some biological functions in the mouse (OF-1 Himberg) by adding them to the animal chow (30 mg/kg/day) for a period of six weeks. No differences in fluid or food uptake could be observed during the feeding period, as compared to a control group. Histology of liver and kidney did not show any changes. Testing routine clinical chemical parameters (serum substrates and enzymes) revealed the following changes: Hex-Ala and But-Abu increased the serum glucose levels. But-Abu dramatically lowered the triglycerides. Serum albumin was increased by Pent-Ala, Me-Val, and But-Abu. LDH was inhibited by But-Abu. |
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| Keywords: | Amino acids Alpha-alkyl-amino acid biology Reaction on triglycerided, -albumin, -glucose Lipid metabolism |
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