1.Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near R.T.O, Pune, 411 001 India ;2.Department of Pharmaceutical Chemistry, AISSMS College of Pharmacy, Kennedy Road, Near R.T.O, Pune, 411 001 Maharashtra India ;3.STES’s Sinhgad College of Pharmacy, Vadgaon(Bk), Pune, 411041 India
Abstract:
Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.
Figure
Evodiamine analogue on sexual behavior in male rats