Conformational feature of neuroactive domoic acid: X-ray structural comparison with isodomoic acid A and alpha-kainic acid. |
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| Authors: | K Nomoto T Takemoto M Maeda Y In M Doi M Inoue T Ishida |
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| Institution: | Suntory Institute for Bioorganic Research, Osaka, Japan. |
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| Abstract: | As an aid for developing a new type of potent insecticide acting on the neuromuscular junction, conformational characteristics of domoic acid and isodomoic acid A, the naturally occurring glutamate agonists, were investigated by X-ray crystal analyses. Conformational comparison with a neuroactive alpha-kainic acid provides information concerning the stereochemical feature responsible for the biological activity. |
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