Cadherins as regulators of neuronal polarity |
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| Authors: | Annette G?rtner Eugenio F Fornasiero Carlos G Dotti |
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| Institution: | 1.VIB Center for the Biology of Disease; KULeuven Center for Human Genetics; Leuven; Belgium, and KULeuven; Department of Development and Regeneration; Leuven, Belgium;2.STED Microscopy of Synaptic Function; European Neuroscience Institute; Göttingen, Germany;3.Centro de Biología Molecular Severo Ochoa; CSIC/UAM; Madrid, Spain |
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| Abstract: | A compelling amount of data is accumulating about the polyphonic role of neuronal cadherins during brain development throughout all developmental stages, starting from the involvement of cadherins in the organization of neurulation up to synapse development and plasticity. Recent work has confirmed that specifically N-cadherins play an important role in asymmetrical cellular processes in developing neurons that are at the basis of polarity. In this review we will summarize recent data, which demonstrate how N-cadherin orchestrates distinct processes of polarity establishment in neurons. |
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| Keywords: | adhesion axon N-cadherin neuronal polarity migration |
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