The baboon model under anesthesia for in vivo cerebral blood flow studies using single photon emission computed tomographic (SPECT) techniques. |
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| Authors: | I Dormehl F Redelinghuys N Hugo D Oliver W Pilloy |
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| Affiliation: | AEC Institute for Life Sciences, University of Pretoria, South Africa. |
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| Abstract: | Single photon emission computed tomography of the brain can be useful in animal experimentation directed toward cerebral conditions. A well established and understood baboon model, necessarily under anesthesia, could be especially valuable in such investigations. Six normal baboons were studied under various anesthetic agents and their combinations: ketamine, thiopentone, pentobarbitone, and halothane. Cerebral blood flow (CBF) studies were performed with 99mTc-HMPAO. CBF effects from various anesthesia were detected, requiring careful choice of the anesthesia for cerebral investigations. |
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| Keywords: | primate model CBF SPECT imaging. |
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