Multiple lineage specific expansions within the guanylyl cyclase gene family |
| |
| Authors: | David A Fitzpatrick Damien M O'Halloran Ann M Burnell |
| |
| Affiliation: | (1) Biology Department, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland;(2) School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland;(3) Center for Neuroscience, UC Davis, 1544 Newton Ct., Davis, CA 95616, USA |
| |
| Abstract: | Background Guanylyl cyclases (GCs) are responsible for the production of the secondary messenger cyclic guanosine monophosphate, which plays important roles in a variety of physiological responses such as vision, olfaction, muscle contraction, homeostatic regulation, cardiovascular and nervous function. There are two types of GCs in animals, soluble (sGCs) which are found ubiquitously in cell cytoplasm, and receptor (rGC) forms which span cell membranes. The complete genomes of several vertebrate and invertebrate species are now available. These data provide a platform to investigate the evolution of GCs across a diverse range of animal phyla. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
