Chargeability measurements of selected pharmaceutical dry powders to assess their electrostatic charge control capabilities |
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Authors: | Juan-Carlos Ramirez-Dorronsoro Robert B Jacko Dane O Kildsig |
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Institution: | (1) Institute of Chemical and Engineering Sciences, 1, Pesek Road, Jurong Island, 627833 Singapore, Singapore;(2) Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117576 Singapore, Singapore;(3) Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, 117543 Singapore, Singapore;(4) Present address: Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 1 University Station, A1920, Austin, Texas 78712, USA |
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Abstract: | The purpose of this study was to develop an instrument (the Purdue instrument) and the corresponding methodologies to measure
the electrostatic charge development (chargeability) of dry powders when they are in dynamic contact with stainless steel
surfaces. The system used an inductive noncontact sensor located inside an aluminum Faraday cage and was optimized to measure
the charging capabilities of a fixed volume of powder (0.5 cc). The chargeability of 5,5-diphenyl-hydantoin, calcium sulfate
dihydrate, cimetidine, 3 grades of colloidal silicon dioxide, magnesium stearate, 4 grades of microcrystalline cellulose,
salicylic acid, sodium carbonate, sodium salicylate, spray-dried lactose, and sulfin-pyrazone were tested at 4 linear velocities,
and the particle size distribution effect was assessed for 3 different grades of colloidal silicon dioxide and 4 different
grades of micro-crystalline cellulose. The chargeability values exhibited a linear relationship for the range of velocities
studied, with colloidal silicon dioxide exhibiting the maximum negative chargeability and with spray-dried lactose being the
only compound to exhibit positive chargeability. The instrument sensitivity was improved by a factor of 2 over the first generation
version, and the electrostatic charge measurements were reproducible with relative standard deviations ranging from nondetectable
to 33.7% (minimum of 3 replicates). These results demonstrate the feasibility of using the Purdue instrument to measure the
electrostatic charge control capabilities of pharmaceutical dry powders with a reasonable level of precision. |
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Keywords: | Powders charge control electrostatic chargeability triboelectricity excipients |
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