| 维生素D受体最新研究进展 |
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| 引用本文： | 崔健,陈虹,黄秉仁.维生素D受体最新研究进展[J].生理科学进展,2011,42(2). |
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| 作者姓名： | 崔健 陈虹 黄秉仁 |
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| 作者单位： | 中国医学科学院基础医学研究所,北京协和医学院,医学分子生物学国家重点实验室,北京,100005 |
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| 摘 要： | 维生素D受体(vitamin D receptor,VDR)是一种核转录因子,通过与配体特异结合,调控多种基因的表达,从而调节多种生命活动的进行.本文总结了近年来VDR的研究进展,主要包括VDR的作用机制、VDR行使功能所需共激活子及共抑制子、VDR在生长分化、免疫调节和抑制肿瘤等方面的作用及VDR配体类似物在药物开发研究领域的最新进展.
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| 关 键 词： | 维生素D受体 维生素D 共激活子 共抑制子 |
The Recent Progress in the Studies of Vitamin D Receptor |
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| CUI Jian,CHEN Hong,HUANG Bing-Ren.The Recent Progress in the Studies of Vitamin D Receptor[J].Progress in Physiological Sciences,2011,42(2). |
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| Authors: | CUI Jian CHEN Hong HUANG Bing-Ren |
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| Institution: | CUI Jian,CHEN Hong,HUANG Bing-Ren(National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100005,China) |
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| Abstract: | Vitamin D receptor(VDR) is a nuclear receptor which can regulate the expression of many kinds of genes by combining with its ligand.This article is about the recent progress in the studies of VDR,including its co-activator,co-repressor,and the function in development,differentiation,immunoregulation and cancer repressor.In the end,we summarized the recent progress in research of drug development about the analog of VDR ligand. |
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| Keywords: | vitamin D receptor vitamin D co-activator co-repressor |
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