'Click peptide': a novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues. |
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Authors: | Youhei Sohma Atsuhiko Taniguchi Taku Yoshiya Yousuke Chiyomori Fukue Fukao Setsuko Nakamura Mariusz Skwarczynski Takuma Okada Keisuke Ikeda Yoshio Hayashi Tooru Kimura Shun Hirota Katsumi Matsuzaki Yoshiaki Kiso |
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Institution: | Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, 21st Century COE Program, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412. |
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Abstract: | After over a decade of studies on aspartic protease inhibitors and water-soluble prodrugs, we have been developing a novel method, since 2003, called 'O-acyl isopeptide method', for the synthesis of peptides containing difficult sequences. With our recent discoveries of 'O-acyl isodipeptide unit' and the 'racemization-free segment condensation method', this method has further evolved as a general synthetic method for peptides. Moreover, 'Click Peptide', which could be a powerful tool for identifying the pathological functions of amyloid beta peptides in Alzheimer's disease, represents a valuable use of the isopeptide method in Chemical Biology-oriented research. |
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