The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans |
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| Authors: | LiHua Hou Bo Jiang Minghua Chen Jennifer Ng Carolyn Katovich Hurley |
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| Institution: | (1) Departments of Oncology, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, E404 Research Building, 3970 Reservoir Road, NW, Washington, DC 20057, USA;(2) Departments of Pediatrics, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, 11333 Woodglen Drive, Rockville, MD 20852, USA; |
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| Abstract: | The frequencies of alleles of killer cell immunoglobulin-like receptor genes, KIR3DL3 and KIR3DL2, and the carrier frequency of KIR2DL4 alleles have been determined from a population of African Americans (n = 100) by DNA sequencing of the coding regions. Fifty alleles of KIR3DL3 were observed with the most frequent, KIR3DL3*00901 (13%). KIR3DL2 was also diverse; 32 alleles with KIR3DL2*00103 the most frequent (17%). For KIR2DL4, of the 18 alleles observed, one allele, KIR2DL4*00103, was found in 64 of the 100 individuals. Thirty-six novel alleles encoding a total of 28 unique receptors are described.
Pairwise comparisons among all of the alleles at each locus suggest a predominance of synonymous substitutions. The variation
at all three framework loci fits a neutral model of evolution. |
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