Structure of presynaptic toxins: Crystallization and preliminary x-ray diffraction data on Notechis II-5, a presynaptic toxin phospholipase |
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| Authors: | K K Kannan S Sinh M Ramanadham D Eaker |
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| Institution: | (1) Neutron Physics Division, Bhabha Atomic Research Centre, 400 085 Bombay;(2) Department of Biochemistry, Uppsala University, Uppsala, Sweden |
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| Abstract: | The presynaptic neutrotoxin-phospholipase, Notechis II-5 from the venom of NotechisScutatus scutatus (Australian tiger snake) has been crystallized in a form suited for x-ray diffraction analysis. The crystals belong to the
orthorhombic space group P21 21,21, with unit cell dimensions, a=146.1,b =43.5 and c =39.0 A. There are two molecules of Notechis II-5 in the asymmetric unit. The molecular weight is about 13,500.
Notechis II-5 is highly homologous to Notexin, another presynaptic toxin from the venom of the Australian tiger snake, to
bovine and porcine pancreatic phospholipases A and other venom phospholipases. |
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| Keywords: | Notechis II-5 Australian tiger snake presynaptic toxin crystallization x-ray diffraction |
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