Biotechnological production and application of ganoderic acids |
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Authors: | Jun-Wei Xu Wei Zhao Jian-Jiang Zhong |
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Institution: | (1) Key Laboratory of Microbial Metabolism (Ministry of Education), School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai, 200240, China; |
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Abstract: | Ganoderic acids (GAs), a kind of highly oxygenated lanostane-type triterpenoids, are important bioactive constituents of the
famous medicinal mushroom Ganoderma lucidum. They have received wide attention in recent years due to extraordinarily pharmacological functions. Submerged fermentation
of G. lucidum is viewed as a promising technology for production of GAs, and substantial efforts have been devoted to process development
for enhancing GA production in the last decade. This article reviews recent publication about fermentative production of GAs
and their potential applications, especially the progresses toward manipulation of fermentation conditions and bioprocessing
strategies are summarized. The biosynthetic pathway of GAs is also outlined. |
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Keywords: | |
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