The renal type IIa Na/Pi cotransporter: structure-function relationships |
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Authors: | Murer Heini Köhler Katja Lambert Georg Stange Gert Biber Jürg Forster Ian |
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Institution: | Physiologisches Institut, Universit?t Zürich, Switzerland. hmurer@access.unizh.ch |
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Abstract: | The type IIa Na/Pi cotransporter mediates proximal tubular brush-border membrane secondary active phosphate (Pi) flux. It is rate limiting in tubular Pi reabsorption and, thus, a final target in many physiological and pathophysiological situations of altered renal Pi handling (1–4). In the present short review, we will briefly summarize our current knowledge about the transport mechanism (cycle) as well
as particular regions of the transporter protein (“molecular domains”) that potentially determine transport characteristics. |
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Keywords: | Phosphate brush border kidney proximal tubule cotransport |
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