Human cryptococcosis: relationship of environmental and clinical strains of <Emphasis Type="Italic">Cryptococcus neoformans</Emphasis> var. <Emphasis Type="Italic">neoformans </Emphasis>from urban and rural areas |
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| Authors: | ACN Delgado H Taguchi Y Mikami M Myiajy MCB Villares ML Moretti |
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| Institution: | (1) Departments of Clinical Pathology, Universidade Estadual de Campinas (UNICAMP), Campinas , Brazil;(2) Internal Medicine, Faculdade de Giências Médicas - Universidade Estadual de Campinas- UNICAMP. Rua Alexandre Fleming , 40 Cidade Universitária Zeferino VAZ, ZIP 13.081-970, Campinas, São Paulo , Brazil;(3) Research Center for Pathogenic Fungi and Microbial Toxicosis, Chiba University, Chiba, Japan |
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| Abstract: | Forty-five clinical and 55 environmental strains of Cryptococcus neoformans var. neoformans from São Paulo, Brazil, were tested for their susceptibilities to amphotericin B, fluconazole, itraconazole, and flucytosine by the broth microdilution method according to the National Committee of Clinical Laboratory Standards guidelines. Electrophoretic karyotypes analysis by counter-clamped homogeneous electrophoresis was used to compare their genetic relatedness. Molecular typing revealed three clinical profiles very similar to two environmental profiles and an identical environmental and clinical profile. The results showed that human cryptococcosis can be acquired from environmental strains, which had similar minimum inhibitory concentration values to clinical strains, for antifungal agents. |
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| Keywords: | acquired immuno deficiency syndrome antifungal susceptibility testing Cryptococcus neoformans molecular typing pigeon droppings |
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