Multiplexed SOI BioFETs |
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Authors: | Vacic Aleksandar Criscione Jason M Stern Eric Rajan Nitin K Fahmy Tarek Reed Mark A |
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Institution: | Department of Electrical, Yale University, 15 Prospect St., New Haven, CT 06511, USA. aleksandar.vacic@yale.edu |
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Abstract: | Nanoscale Field Effect Transistors have emerged as a promising technology for ultrasensitive, unlabeled diagnostic applications. However, their use as quantitative sensors has been problematic because of the need for individual sensor calibration. In this work we demonstrate an internal calibration scheme for multiplexed nanoribbon field effect sensors by utilizing the initial current rates rather than end point detection. A linear response is observed consistent with initial binding kinetics. Moreover, we are able to show that top-down fabrication techniques yield reproducible device results with minimal fluctuations, enabling internal calibration. |
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