Neuropeptide Y inhibits human and invertebrate immunocyte chemotaxis,chemokinesis, and spontaneous activation |
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| Authors: | Paul Dureus Dahla Louis Anthony V Grant Thomas V Bilfinger George B Stefano |
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| Institution: | 1. Multidisciplinary Center for the Study of Aging, Old Westbury Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, Old Westbury, New York, USA
2. Department of Surgery, Health Sciences Center, State University of New York at Stony Brook, 11794, Stony Brook, New York, USA
3. Neuroscience Research Institute, State University of New York, College at Old Westbury, 11568, Old Westbury, New York, USA
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| Abstract: | | 1. |
In a concentration-dependent manner neuropeptide Y was found to be a potent inhibitor of the spontaneous activation of human granulocytes and macrophages as well asMytilus edulis immunocytes.
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Neuropeptide Y also inhibited the chemotaxic response of these immunocytes to the chemoattractant f-MLP.
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Incubation of both the human and the invertebrate immunocytes in f-MLP (10–9
M) causes  activation as noted by random locomotion (chemokinesis). Neuropeptide Y also blocked f-MLP-induced chemokinesis.
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The results suggest that neuropeptide Y may, in addition to other functions, serve as an endogenous regulator of immunocyte function.
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| Keywords: | neuropeptide Y f-MLP chemotaxis chemokinesis granulocytes macrophages invertebrate immunocytes |
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