The beneficial effect of OST-6 (OsteoCare), a herbomineral formulation, in experimental osteoporosis. |
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| Authors: | S K Mitra M V Venkataranganna U V Udupa S Gopumadhavan S J Seshadri M Rafiq S D Anturlikar R Sundaram M Tripathi |
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| Institution: | Department of Pharmacology, R&D Center, The Himalaya Drug Company, Makali, Bangalore, India. hdcrd@bgl.vsnl.net.in |
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| Abstract: | OST-6 (OsteoCare), a herbomineral formulation, was evaluated for its inhibitory effect on the progress of bone loss induced by ovariectomy in rats. Ovariectomized (Ovx) rats were administered with OST-6 at 250 and 500 mg/kg b.wt., orally daily for 90 days. On 91st day, ovariectomized rats showed reduced bone mineral content and increased serum alkaline phosphatase levels, excretion of urinary calcium and pyridinium cross-links levels. Histologically, bone sections revealed narrowed and disappearance of trabeculae and widened medullary spaces. The total numbers of Tartrate-resistant acid phosphatase (TRAP) positive cells were significantly increased both in-vivo and in-vitro methods. OST-6, at a dose of 500 mg/kg, significantly improved bone mineral contents, serum alkaline phosphatase levels, reduced the elevated urinary calcium and pyridinium cross-links excretion, number of TRAP positive cells and reversal of the above mentioned histological features. These results indicate the usefulness of OST-6 in the management of osteoporosis in a natural way through herbal resources. |
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