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Magnetic resonance spectroscopy of normal appearing white matter in early relapsing-remitting multiple sclerosis: correlations between disability and spectroscopy |
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| Authors: | Juan?Luis?Ruiz-Pe?a Pilar?Pi?ero Guillermo?Sellers Joaquín?Argente Alfredo?Casado Jesus?Foronda Antonio?Uclés |
| Institution: | 1.Unidad de Esclerosis Múltiple,Hospital Universitario Virgen Macarena,Sevilla,Espa?a;2.Servicio de Radiología,Clínica Sagrado Corazón,Sevilla,Espa?a;3.Centro de Investigación y Bioestadística,Madrid,Espa?a;4.Servicio de Neurología,Hospital Puerta del Mar,Cádiz,Espa?a;5.Servicio de Neurología,Hospital San Cecilio,Granada,Espa?a;6.Servicio de Neurología,Hospital de Jaén,Jaén,Espa?a;7.Servicio de Neurología,Hospital Virgen del Rocío,Sevilla,Espa?a;8.Servicio de Radiología,Hospital Virgen del Rocío,Sevilla,Espa?a |
| Abstract: | BackgroundWhat currently appears to be irreversible axonal loss in normal appearing white matter, measured by proton magnetic resonance spectroscopy is of great interest in the study of Multiple Sclerosis. Our aim is to determine the axonal damage in normal appearing white matter measured by magnetic resonance spectroscopy and to correlate this with the functional disability measured by Multiple Sclerosis Functional Composite scale, Neurological Rating Scale, Ambulation Index scale, and Expanded Disability Scale Score. |
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