Low serum PON1 activity: an independent risk factor for coronary artery disease in North-West Indian type 2 diabetics |
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| Authors: | Gupta Nidhi Binu K B K Singh Surjit Maturu Nagarjuna V Sharma Yash P Bhansali Anil Gill Kiran Dip |
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| Affiliation: | a Graduate School of Environment and Information Science, Yokohama National University, Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japanb Interdisciplinary Research Center, Yokohama National University, Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japanc Laboratory of Molecular Biology, Faculty of Engineering Science, Yokohama National University, Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan |
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| Abstract: | Posttranslational modifications of proteins have profound effects on many aspects of their function and have received much attention due to the importance of these processes in epigenetic regulation. In this study, we report that deleted azoospermia associated protein 1 (DAZAP1)/proline-rich RNA binding protein (Prrp), a multifunctional RNA binding protein which is essential for spermatogenesis and normal cell growth, is acetylated at Lysine 150 within its RNA binding domain. The acetylation is predominantly observed in nuclear Prrp, and the nonacetylated form is in cytoplasm. Considering that Prrp is a shuttling protein, we suggest that the acetylation cycle at Prrp K150 regulates nucleocytoplasmic transport in cells. |
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| Keywords: | anti-panAcK, Anti-pan-specific acetylated-lysine K150, Lysine 150 MoAb, monoclonal antibody NLS, nuclear localization signal PEI, polyethylenimine Prrp, proline-rich RNA binding protein PTM, posttranslational modification RRM, RNA recognition motif |
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