Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women |
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| Authors: | Jeon Young Joo Choi Yi Seul Rah Hyungchul Kim Su Yeoun Choi Dong Hee Cha Sun Hee Shin Ji Eun Shim Sung Han Lee Woo Sik Kim Nam Keun |
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| Institution: | a Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Koreab Department of Biomedical Science, College of Life Science, CHA University, Seongnam, Republic of Koreac Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Koread Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul, Republic of Korea |
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| Abstract: | AimThe aim of this study was to investigate the association of microRNA polymorphisms (miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G) in Korean patients with recurrent spontaneous abortion (RSA).MethodsWe conducted a case-control study of 564 Korean women: 330 patients with at least two unexplained consecutive pregnancy losses and 234 healthy controls with at least one live birth and no history of pregnancy loss.ResultsRSA patients exhibited significantly different frequencies of the miR-196a2CC (TT+TC vs. CC; adjusted odds ratio AOR], 1.587; 95% confidence interval CI], 1.042-2.417) and miR-499AG+GG genotypes (AOR, 1.671; 95% CI, 1.054-2.651) compared with the control group. The combination of miR-196a2CC and miR-499AG+GG showed synergistic effects (AOR, 3.541; 95% CI, 1.645-7.624).ConclusionmiR-196a2CC, miR-499AG+GG, and the miR-196a2CC/miR-499AG+GG combination are significantly associated with idiopathic RSA in Korean women. |
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| Keywords: | miRNA microRNA pri-miRNA primary miRNA pre-miRNA premature miRNA RSA recurrent spontaneous abortion SNP single nucleotide polymorphism OR odds ratio CI confidence interval |
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