Vertebrate evolution reflected in the evolution of nuclear ribosomal internal transcribed spacer 2 |
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| Authors: | Natalia Kupriyanova Dmitrii Shibalev Alexander Voronov Kirill Netchvolodov Tatiana Kurako Alexei Ryskov |
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| Affiliation: | a Department of Life Science, College of Science, National Taiwan Normal University, Taipei 116, Taiwanb Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwanc Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan |
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| Abstract: | Plastics are widely used in modern life, and their unbound chemicals bisphenol A and phthalates can leach out into the surrounding environment. BPA and PAEs have recently attracted the special attention of the scientific community, regulatory agencies and the general public because of their high production volume, widespread use of plastics, and endocrine-disrupting effects. In The Comparative Toxicogenomics Database, BPA and five most frequently curated PAEs (DEHP/MEHP and DBP/BBP/MBP) were found to have 1932 and 484 interactions with genes/proteins, respectively. Five of their top ten toxicity networks were found to be involved in inflammation, and their top ten diseases included genital, prostatic, endomentrial, ovarian and breast diseases. BPA and PAEs were found to exhibit similar toxicogenomics and adverse effects on human health owning to their 89 common interacting genes/proteins. These 89 genes/proteins may serve as biomarkers to assay the toxicities of different chemicals leached out from the widely used plastics. |
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| Keywords: | BBP, butylbenzyl phthalate BPA, bisphenol A, 2,2-bis(4-hydroxyphenyl) propane CTD, Comparative Toxicogenomics Database DBP, Dibutyl phthalate DEHP, Diethylhexyl phthalate GO, GeneOntology IPA, Ingenuity Pathways Analysis MBP, monobutyl phthalate MEHP, Mono-(2-ethylhexyl) phthalate PVC, polyvinyl chloride |
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