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Ethanol induced conformational changes of the peptide ligands for the opioid receptors and their relevance to receptor interaction |
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| Authors: | R S Rapaka V Renugopalakrishnan T J Goehl B J Collins |
| Institution: | 1. Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Ave., Lawrence, KS 66047, USA;2. Medimmune Inc.-AstraZeneca, Gaithersburg, MD 20878, USA;1. Laboratory of Quantum and Statistical Physics LR 18 ES 18, Faculty of sciences of Monastir, Environnement Street, 5019 Monastir, Tunisia;2. Department of Physics, College of Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia;3. Department of Computer Science, College of Science and Arts at Muhayel, King Khalid University, Saudi Arabia |
| Abstract: | The FT-IR (Fourier Transform Infrared) Spectrum of Met 5]-enkephalinamide in aqueous solution shows the presence of both the beta-turn and beta-sheet conformations. The beta-turn and beta-sheet conformations of enkephalins have been proposed to play a role in receptor selectivity. Addition of ethanol alters these secondary structural features and hence the effect of ethanol on ligand-receptor interaction may be mediated primarily through conformational changes of the ligand rather than those of the receptor. |
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