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The evaluation of protective and mitigating effects of vitamin C against side effects induced by radioiodine therapy |
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| Authors: | Esmail?Jafari,Mehrosadat?Alavi author-information" > author-information__contact u-icon-before" > mailto:alavimh@sums.ac.ir" title=" alavimh@sums.ac.ir" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Fatemeh?Zal |
| Affiliation: | 1.Department of Medical Physics, Medicine School,Shiraz University of Medical Sciences,Shiraz,Iran;2.Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC),Shiraz University of Medical Sciences,Shiraz,Iran;3.Department of Nuclear Medicine, Medicine School,Shiraz University of Medical Sciences,Shiraz,Iran;4.Biochemistry Department, Medical School,Shiraz University of Medical Sciences,Shiraz,Iran;5.Department of Nuclear Medicine,Namazi Hospital,Shiraz,Iran |
| Abstract: | The goal of this study was to evaluate the protective and mitigative effect of vitamin C on oxidative stress in differentiated thyroid cancer (DTC) patients ablated with radioiodine. 58 DTC patients selected for radioactive iodine therapy (RAIT) with 5550 MBq 131Iodine were divided into four groups. Group 1 (control group) consisted of patients who underwent RAIT routinely. Other patients received 1500 mg vitamin C daily 2 days after (group 2), 2 days before to 2 days after (group 3) and 2 days before RAIT (group 4). Serum oxidative stress markers including malondialdehyde (MDA), glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) were measured immediately before and 2 days after RAIT. A significant increase in MDA after RAIT was observed in all groups (p?p?p?p?p?p?p?p?>?0.05). A significant increase was observed in CAT activity after RAIT in all groups (p?p?p? |
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