Novel synthesis and anti-inflammatory activities of 2,5-disubstituted-dioxacycloalkanes |
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| Authors: | Bi Lanrong Zhang Yue Zhao Ming Wang Chao Chan Priscilla Tok Jeffrey B-H Peng Shiqi |
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| Affiliation: | College of Pharmaceutical Sciences, Capital University of Medical Sciences, Beijing 100054, PR China. |
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| Abstract: | A novel stereospecific synthetic route to obtain a series of 2,5-disubstituted-dioxacycloalkanes is reported. Using an in vivo inhibition assay by monitoring xylene-induced ear edema in mice, the structure-activity relationship of the dioxacycloalkane compounds was studied, and compounds possessing high anti-inflammatory activity were identified. |
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