血红素加氧酶-1、树突状细胞和调节性T细胞在慢性气道炎症中的作用及相互关系

慢性气道炎症是多种肺部疾病的共同病理生理过程,是由多种炎症细胞、炎症介质及细胞因子相互作用所致的气道病变。血红素加氧酶(HO)-1、树突状细胞(DC)和调节性T细胞(Treg)参与了气道炎症并发挥不同的作用,表现在HO-1具有抗炎抗氧化及保护细胞的作用;DC除可导致或持续气道炎症反应外,也具有负向调控作用,可诱导免疫耐受而抑制炎症的发展;而Treg可发挥免疫调抑功能,以此维持免疫稳态及抑制气道炎症。HO-1、DC和Treg相互作用,影响着气道炎症的发生发展。现对三者在气道炎症中的作用及相互关系进行综述。

The Roles and Interactions of Heme Oxygenase-1, Dendritic Cell and Regulatory T Cell in Airway Inflammation

Chronic airway inflammation is the common pathological process of many kinds of pulmonary diseases, there are several of cells, mediators and cytokines of inflammation those interact and result in various kinds of pathological changes of airway. Heme oxygenase-1 (HO-1), dendritic cell (DC) and regulatory T cell (Treg) have different mechanisms of action in airway inflammation. HO-1 has the effects of anti-inflammatory and anti- oxidation to protect cells against inflammatory injury, DC can induce persistence of airway inflammation while DC subsets with tolerogenic properties can induce immunotolerance to suppress development of airway inflammation, Treg can play an important role in regulating or suppressing immune responses to maintain immune homeostasis. They can interact in the development of airway inflammation. This article provides a review of the recent studies about their functions and interactions in chronic airway inflammation.