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Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer |
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| Authors: | TRJeffry Evans Martin G Rowlands Marizilka C Silva Matthew Law RCharles Coombes |
| Institution: | 1 Department of Medical Oncology, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, England 2 Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, England 3 Department of Medical Oncology, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, England |
| Abstract: | The aromatase and estrone sulfatase enzymes are important sources of local synthesis of biologically active estrogens in human breast cancer. Significant intratumoral aromatase activity was detected in 91/145 (63%) of tumors and estrone sulfatase was detected in 93/104 (89%) of tumors. There was no relationship between aromatase activity and tumor size, site, nodal status, menopousal status or estrogen receptor status. There was a significant correlation between the aromatase activity and histological grade, with an excess of aromatase-positive in the high grade tumors (P = 0.03). There was a marginally inverse correlation between the aromatase activity and time to relapse (P < 0.1), a significant correlation between aromatase activity and survival after relapse (P < 0.05) but not with overall survival (P < 0.1). Intratumoral estrone sulfatase activity was not significantly correlated to any putative prognostic factors, nor with time to relapse nor overall survival time. |
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