Biosynthesis of the major scent components 3,5-dimethoxytoluene and 1,3,5-trimethoxybenzene by novel rose O-methyltransferases |
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Authors: | Scalliet Gabriel Journot Noellie Jullien Frédéric Baudino Sylvie Magnard Jean Louis Channelière Stéphanie Vergne Philippe Dumas Christian Bendahmane Mohammed Cock J Mark Hugueney Philippe |
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Institution: | Institute of Bioinformatics, Department of Biological Sciences and Biotechnology, Tsinghua University, 100084, Beijing, PR China. |
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Abstract: | In an effort to determine putative functional relationships between gene expression patterns and drug activity patterns of 60 human cancer cell lines, a novel method was developed to discover local associations within cell line subsets. The association of drug-gene pairs is an explorative way of discovering gene markers that predict clinical tumor sensitivity to therapy. Nine drug-gene networks were discovered, as well as dozens of gene-gene and drug-drug networks. Three drug-gene networks with well studied members were discussed and the literature shows that hypothetical functional relationships exist. Therefore, this method enables the gathering of new information beyond global associations. |
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