Enantioseparation, absolute configuration determination, and anticonvulsant activity of (+/-)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one |
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Authors: | Calabrò Maria Luisa Raneri Daniela Ficarra Paola Ferreri Guido De Sarro Giovambattista Bruno Giuseppe Zappalà Maria Micale Nicola Grasso Silvana |
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Institution: | Dipartimento Farmaco-Chimico, Università di Messina, Messina, Italy. |
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Abstract: | The resolution of 1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-benzodiazepin-4-one (+/-)-(R,S)-2 was accomplished by chiral HPLC. The absolute configuration of (+)-2, determined by X-ray crystallographic analysis, was R. The in vivo anticonvulsant activity of the enantiomers (+)-(R)-2 and (-)-(S)-2 is reported. It has been also demonstrated that compound (+/-)-(R,S)-2 in vivo undergoes oxidative metabolism to derivative 1. |
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Keywords: | resolution chiral HPLC X‐ray crystallography audiogenic seizures 2 3‐benzodiazepin‐4‐one |
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