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Insulin resistance increases PAI-1 in the heart
Authors:Sobel Burton E  Schneider David J  Lee Yong-Ho  Pratley Richard E
Institution:University of Vermont, Cardiovascular Research Institute Burlington, VT, USA. burt.sobel@vtmednet.org
Abstract:To determine whether insulin resistance increases expression of plasminogen activator inhibitor type-1 (PAI-1) in the heart, studies were performed in 22 mice with and 38 without myocardial infarction. Insulin resistance in transgenic animals genetically rendered insulin resistant was confirmed with the use of intraperitoneal glucose tolerance tests. Myocardial infarction was induced by coronary ligation, verified echocardiographically, and quantified by assay of depletion of creatine kinase (CK) from the left ventricle 2 weeks later. PAI-1 increased markedly in zones of infarction to 10.4+/-2.1 (SF) and significantly more to 27.3+/-3.6 in normal and insulin resistant mice compared with 0.45+/-0.04 and 0.50+/-0.03 in normal myocardium. Thus, insulin resistance induced accumulation of PAI-1 in the heart, particularly in zones of infarction. Such increases may contribute to fibrosis and diastolic dysfunction typical late after infarction in patients with insulin resistance.
Keywords:Cardiomyopathy  Fibrosis  Heart failure  Infarction  Insulin resistance
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