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Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: metabolism-directed optimization studies towards orally bioavailable derivatives |
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| Authors: | Vergne Fabrice Bernardelli Patrick Lorthiois Edwige Pham Nga Proust Emmanuelle Oliveira Chrystelle Mafroud Abdel-Kader Ducrot Pierre Wrigglesworth Roger Berlioz-Seux Françoise Coleon Francis Chevalier Eric Moreau François Idrissi Moulay Tertre Anita Descours Arnaud Berna Patrick Li Mei |
| Affiliation: | Pfizer Global Research and Development, 3-9 Rue de la loge 94265 Fresnes, France. fabrice.vergne@aventis.com |
| Abstract: | The synthesis and optimization of pharmacokinetic parameters of structurally novel small PDE7 inhibitors is discussed. |
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| 本文献已被 PubMed 等数据库收录！ | |