磺化铝酞菁的磺化程度对光敏活性的影响

磺化铝酞菁为新一代的光敏剂,为了研究其平均磺化程度对光敏活性的影响,本文比较测定了平均磺化度为三的铝酞菁Alpcs(3)及平均磺化度为二的铝酞菁A1pcs(2)的单态氧(~1O)产率,细胞的吸收及光敏杀伤。结果表明,磺化度的不同并不影响~1O_2的生成及细胞的吸收动力学规律,但人体肝癌细胞对Alpcs(2)的摄入量比Alpcs(3)高出5倍左右,且Alpcs(2)比Alpcs(3)对癌细胞有更强的光敏杀伤效应。提示,可通过调节降低磺化程度,增进细胞吸收,获得更佳的光敏效率。

THE EFFECT OF SULFONATION DEGREE OF ALUMINUM PHTHALOCYANINE ON PHOTOSENSITIVE ACTIVITIES

Sulfonated aluminum phthalocyanine (A1PCS) is a new class of photosensiti-zer. In order to clarify the effect of average sulfonation degree of aluminumphthalocyanine on photosensitive activities; a comparative study of AIPCS (3) and AIPCS(2) on their ability of singlet oxygen (1O2) generation, cellular uptake and photokilling of cancer cells were made. The results showed that the difference of sulfonation degree did not affect the 1O2 production and kinetics of cellular uptake, hut the amount of cell-associated A1PCS (2) was 5 times higher than that of cell-associated A1PCS(3), so the cancer cells were damaged more severely by A1PCS(2) than A1PCS(3) under red light irradiation. It was suggested that lowering of average sulfonation degree enhanced its cell penetration and obtained a better photosensitive efficiency to photokill cancer cells.